Optical imaging for improved detection and surgery of solid tumors
- Conditions
- breast cancer, sentinel lymph node, intraoperative imaging, image-guided surgery
- Registration Number
- NL-OMON21271
- Lead Sponsor
- Department of Surgery, University Medical Center Groningen
- Brief Summary
Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Tagaya N, Yamazaki R, Nakagawa A, Abe A, Kiyoshige H, Kubota K, Oyama T. Am J Surg 2008;195:850-853. <br><br> - Evaluation of breast lymphatic pathways with indocyanine green fluorescence imaging in patients with breast cancer. Ogasawara Y, Ikeda H, Takahashi M, Karasaki K, Doihara H. World J Surg 2008;32:1924-1929. <br><br> - Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluophore: Feasibility study. Sevick-Muraca EM, Sharma R, Rasmussen JC, Marshall MV, Wendt JA, Pham HQ, Bonefas E, Houston JP, Sampath L, Adams KE, Blachard DK, Fischer RE, Chiang SB, Elledge R, Mawad ME. Radiology 2008; 246: 734-741. <br><br>
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
1. Patients with operable invasive breast cancer stage (T1-2N0-1 – stage I and II) proven by histology on a biopsy.
1. Pregnant women.
2. Significant renal (creatinine >, cardiac, or pulmonary disease (ASA III-IV).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Ergonomics and function of the NIRF imaging system - the NIRF imaging system must not interfere with the standard Sentinel Lymph Node mapping procedure and should be used safely by the surgeon. <br />Duration of data aquisition: 1,5 hour clinical procedure.
- Secondary Outcome Measures
Name Time Method Identify sentinel lymph nodes within the allocated procedure (usually 1-1,5 hour)