A randomized controlled Studyfor clinical evaluation of synergistic effect of oral bisphosphonate with Platelets rich plasma in knee Osteoarthritis - ALNPRP

Amit Kumar0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年3月6日

试验速览

暂无简介。

•Early stage of Degenerative osteoarthritis of knee
•1.History of pain for the last 3 months according to the ACR criteria for knee osteoarthritis along with radiologic evidence of joint changes based on Kellgren-Lawrence criteria (including grades 1,2 and 3).
•2.Mild radiographic OA of the medial compartment (medial tibiofemoral joint space <= 2 mm on a weightbearing fixed flexion PA view/Rosenberg view);
•3.Mild varus malalignment by clinical examination

•1.Age <50 years and >75 years
•2.Any form of knee injection such as visco-supplements, ozone etc. in the preceding 3 months;
•3.Having arthroscopic or open surgery in the past 6 months;
•4.Having metabolic bone disease immunodeficiency, autoimmune disease, collagen vascular disease, or diabetes;
•5.History of cancer;
•6.Infection or inflamed lesion in the knee;
•7.Platelet disorder or disease;
•8.Use of anticoagulant or anti-platelet medication 10 days before injection;
•9.Use of NSAIDs 2 days before injection;
•10.Corticosteroid knee injection 3 weeks before injection or use of systemic corticosteroids 2 weeks before the injection;
•11.Hemoglobin level less than 10 g/dL and platelets less than 150,000/microliter;
•12.History of severe knee trauma;
•13.Pregnancy and lactation;
•14.Hypersensitivity to Bisphoshphonate
•15.History of Renal impairment
•16.Non-reactive for HIV, HBsAg and HCV by chemiluminscence
•17.In diabetic patients Fasting blood sugar less than 110mg/dl and HbA1c less than 7.5 %

发起方

Amit Kumar