The Effect of Creatine Supplementation on Muscle Loss During Immobilisation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- change in quadriceps muscle cross-sectional area (CSA)
研究概览
简要总结
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.
详细描述
Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determined and muscle biopsies will be collected before and immediately after immobilisation. A week after the cast is removed we will assess any differences in recovery between intervention groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged from 18-35 years
- •18.5 < BMI < 30 kg/m2
排除标准
- •(Family) history of thrombosis
- •Recent surgery
- •Performing regular resistance training more than once per week in the past year
- •Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
- •Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
- •All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- •Use of anti-coagulants
- •Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
结局指标
主要结局
change in quadriceps muscle cross-sectional area (CSA)
时间窗: Before and after 1 week of immobilisation, and after 1 week of recovery
immediately before and after 1 week of immobilisation, and after 1 week recovery, quadriceps CSA will be assessed
次要结局
- change in muscle strength(before and after 1 week of immobilisation, and after 1 week of recovery)
- change in muscle fiber type specific CSA(Before and after 1 week of immobilisation, and after 1 week of recovery)