Genetic Biomarkers in Tissue Samples From Patients With Osteosarcoma
- Conditions
- Osteosarcoma
- Interventions
- Other: laboratory biomarker analysis
- Registration Number
- NCT01807143
- Lead Sponsor
- Children's Oncology Group
- Brief Summary
This clinical trial studies genetic biomarkers in tissue samples from patients with osteosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer
- Detailed Description
Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study Population Description: Samples from the COG Sampling Method: Non-Probability Sample
PRIMARY OBJECTIVES:
I. To use PET sequencing to analyze DNA from ten human primary osteosarcoma samples, along with matched normal tissue where available.
OUTLINE:
Tissue samples are analyzed for translocations and deletions and analyzed using polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Samples from the COG tissue repository
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Correlative studies laboratory biomarker analysis Tissue samples are analyzed for translocations and deletions and analyzed using PCR or FISH.
- Primary Outcome Measures
Name Time Method Mapping and filtering of paired tags Up to 2 years Mapping of paired tags to reference genomes to identify aberrant pairs, caused by translocations, insertions, deletions and inversions.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Oncology Group
🇺🇸Monrovia, California, United States
Children's Oncology Group🇺🇸Monrovia, California, United States