Double vs Dual Trigger in POSEIDON 3–4: A Multicenter RCT on Embryo quality in Poor Responders

This randomized controlled study aims to compare the embryological outcomes with two trigger protocols for oocyte maturation- the dual trigger consisting of Inj hCG and Inj GnRH agonist given together at 35- 36 hours before oocyte retrieval vs double trigger- Inj GnRH agonist given 38-40 hours prior vs Inj hCG given 34- 35 hours before oocyte retrieval.

The study will evaluate the difference in oocyte retrieval rate, maturity rate, fertilization rate, premature ovulation rate, blastulation rate and top quality embryo rate between the two groups. The patients would be further analysed under the subgroups based on the protocol used (PPOS vs GnRH antagonist) and the age of the patients studied (<35 years and >35 years old).

Since there are no previous randomized controlled trials comparing outcomes using these two trigger strategies in this population of patients, this study aims to identify the optimal trigger strategy to maximize the oocyte maturity rate and embryological outcomes in poor responder patients.

We aim to include 150 patients in this study over a period of 1 year.