Evaluation of oral calcium effect in prevention OHSS (ovarian hyperstimulation syndrome) in high-risk patients
Phase 3
- Conditions
- Female infertility associated with anovulationOHSS(ovarian hyperstimulation syndrome).
- Registration Number
- IRCT20170417033490N2
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 150
Inclusion Criteria
1- Antagonist protocol for Assisted reproductive technology (ART)
2- ) 2- The number of follicles = 20 mm is over 20.
3- The plasma estradiol level = 2500pg/ml
Exclusion Criteria
1-patients with the endocrine disease as Diabetes mellitus, hyperprolactinemia, Cushing disease, congenital adrenal hyperplasia
2- Patients with the systemic disease as asthma, collagen vascular disease, hypercholesterolemia, cycle cell anemia
3- History of neoplasm
4-The plasma estradiol level is high (over 6000pg/ml).
5- Use of insulin-sensitization drugs
6- Patients that were required to the need to cycle cancellation.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevention of ovarian hyper stimulation syndrome. Timepoint: 7 to 14 days after administration of drug. Method of measurement: physical exam, transvaginal sonography and blood exam.
- Secondary Outcome Measures
Name Time Method