Metagenome analysis of chronic otitis media - Metagenome analysis of chronic otitis media

The children and adults with normal middle ears differed significantly in terms of middle ear microbiomes. Subjects with chronic otitis media without active inflammation had similar middle ear microbiomes as the normal middle ears group. Subjects with chronic otitis media with active inflammation had a lower prevalence of Proteobacteria and a higher prevalence of Firmicutes than the normal middle ears.