跳至主要内容
临床试验/NCT07454564
NCT07454564招募中不适用

Investigation of the Relationship Between Preoperative Cardiac Power Output and P-POSSUM Score

Necmettin Erbakan University1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2026年3月10日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
120
试验地点
1
主要终点
30-day postoperative mortality

研究概览

简要总结

This study aims to investigate the relationship between preoperative Cardiac Power Output (CPO), which reflects the pumping capacity of the heart, and the P-POSSUM score, a widely used surgical risk assessment tool, in patients aged 65 years and older undergoing abdominal surgery. Simple and non-invasive measurements performed in the preoperative period will be used to obtain CPO values and to evaluate whether these measurements are helpful in predicting postoperative morbidity and mortality. No additional procedures beyond routine clinical care will be performed as part of this observational study. The findings of this study may contribute to a more accurate assessment of surgical risk and help improve patient safety in the perioperative period.

详细描述

This is a prospective, observational study designed to evaluate the relationship between preoperative Cardiac Power Output (CPO) and the P-POSSUM risk score in patients aged 65 years and older undergoing abdominal surgery, including both elective and emergency procedures. CPO is a hemodynamic parameter reflecting overall cardiac pumping power and may provide additional physiologic information beyond traditional risk models. P-POSSUM is widely used to estimate postoperative morbidity and mortality based on physiological and operative variables.

Eligible patients will be assessed in the preoperative period. Preoperative CPO will be obtained using non-invasive hemodynamic measurements as part of routine perioperative practice. The P-POSSUM score will be calculated for each patient using standard definitions. Patients will be followed during the postoperative period to document clinical outcomes, including postoperative complications and mortality within the predefined follow-up window, as well as length of hospital stay when available.

The primary objective is to assess the association between preoperative CPO and the P-POSSUM score. Secondary objectives include exploring whether preoperative CPO is associated with postoperative outcomes and whether it may help refine perioperative risk stratification. This study does not involve any investigational treatment; no additional interventions beyond standard clinical care will be performed. All data will be handled in accordance with applicable privacy and confidentiality regulations, and patient identifiers will not be included in the analysis dataset.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Being 65 years of age or older,
  • Undergoing abdominal surgery in general surgery practice (including elective and emergency procedures),
  • ASA (American Society of Anesthesiologists) class I-III,
  • Adequate recording with transthoracic echocardiography,
  • Having given informed consent.

排除标准

  • Advanced heart failure with ejection fraction (EF) <30%,
  • Severe valvular disease (severe stenosis or insufficiency),
  • Unstable coronary artery disease or recent myocardial infarction (within the last 3 months),
  • Pulmonary hypertension,
  • Severe arrhythmia (uncontrolled atrial fibrillation, ventricular tachycardia, etc.)

研究组 & 干预措施

patients aged 65 years and older undergoing abdominal surgery

This cohort consists of patients aged 65 years and older undergoing abdominal surgery, including both elective and emergency procedures. All participants will undergo preoperative evaluation, including non-invasive measurement of Cardiac Power Output (CPO) and calculation of the P-POSSUM score, as part of routine clinical assessment. No experimental intervention will be performed in this study, and all patients will receive standard clinical care and follow-up. Postoperative clinical outcomes will be recorded prospectively.

结局指标

主要结局

30-day postoperative mortality

时间窗: Up to 30 days after surgery

All-cause mortality occurring within 30 days after abdominal surgery in patients aged 65 years and older (yes/no).

次要结局

  • Postoperative morbidity(Up to 30 days after surgery)
  • Early postoperative morbidity(Postoperative day 3)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

ŞULE ARICAN

Assoc.Prof.MD

Necmettin Erbakan University

研究点 (1)

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