Investigating normal variability in brain volumes and cognition in a healthy population. - Normal variability in brain volumes and cognition

niversitair Medisch Centrum Utrecht0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•1) Age between 18 and 70 years
•2) Written informed consent is obtained
•3) Female subjects with child-bearing potential need to utilize a proper method of contraception (the pill, vaginal ring, hormonal patch, intrauterine device, cervical cape, condom, contraceptive injection, diaphragm) in case of sexual during the study

•1) MRI contra-indications, e.g.
•i. Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
•ii. Claustrophobia
•2) Family history with psychiatric illness (i.e. participants themselves, parents, brothers or sisters of the participant
•3) Chronic use of glucocorticosteroids (temporary use is permitted, if stopped at least 1 month before start of the study)
•4) Chronic use of non-steroidal anti-inflammatory drugs
•5) Current use of statins or other lipid-lowering drugs
•6) Pregnancy or breast-feeding (urine pregnancy test will be performed for sexually active females with child bearing potential)
•7) Presence of diabetes mellitus, severe heart failure, severe osteoporosis or systemic fungal infections as reported by the participant
•8) Concurrent use of certain types of medication:
•i. liver enzyme inducing medication such as carbamazepine, riphampicine, primidone,
•barbiturates and phenytoine
•ii. HAART (both HIV protease inhibitors and (non)-nucleoside reverse transcriptase
•inhibitors), especially efavirenz, ritonavir and lopinavir.
•iii. telaprevir and boceprevir in treatment of Hepatitis C

发起方

niversitair Medisch Centrum Utrecht