The Aerobic and Cognitive Training System

Not Applicable

Completed

• Conditions: Healthy Aging
• Interventions: Behavioral: Simultaneous exercise and cognitive training; Behavioral: Exercise training; Behavioral: Cognitive Training; Behavioral: Neutral video

• Registration Number: NCT04120792
• Lead Sponsor: University of Arizona

Brief Summary

This study will determine the effects of simultaneous exercise and cognitive training on cognitive function in healthy older adults. Specifically, this study will compare the use of a tablet-based cognitive training system while exercising with exercise alone, cognitive training alone, and a neutral control condition on cognition.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-01
• Primary Completion: 2017-11-20
• Study Completion: 2017-11-20
• Status Verified: 2019-05
• Study First Submitted: 2019-10-04
• Study First Submitted QC: 2019-10-07
• Last Update Submitted: 2019-10-07
• Study First Posted: 2019-10-09
• Last Update Posted: 2019-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

Generally healthy, age 60-74, and a written statement from their primary care physician indicating that they are able to participate in the 12-week exercise program.

Exclusion Criteria

Subjects will be excluded from participating in the study if they express significant concerns about their memory or declines in other cognitive abilities, if they are not English speaking, or if they have histories of significant major neurological, psychiatric, or medical disorder or injury that would affect cognitive function.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Simultaneous exercise and cognitive training	Simultaneous exercise and cognitive training	Participants in this arm will engage in a 12-week intervention that combines physical exercise and cognitive tablet-based training. This intervention involves use of an exercise bicycle while engaging in cognitive tasks on a tablet computer three times per week.
Exercise training	Exercise training	Participants in this arm will engage in a 12-week exercise intervention that involves use of an exercise bicycle three times per week.
Cognitive training	Cognitive Training	Participants in this arm will engage in a 12-week intervention that involves cognitive tablet-based training three times per week.
Neutral Video	Neutral video	Participants in this arm will engage in a 12-week intervention that involves watching neutral videos on a tablet computer three times per week.

Primary Outcome Measures

Name	Time	Method
Change from baseline in cognitive function during dual-task test at 12 weeks	Baseline and 12-weeks	Performance on serial subtraction during dual-task walking.

Secondary Outcome Measures

Name	Time	Method
Change from baseline in stride length during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride length in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in stride duration during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride duration in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in stride velocity during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride velocity in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in stride duration variability during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride duration variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in stride velocity variability during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride velocity variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in stride length variability during dual-task test	Baseline, 6 weeks, 12 weeks	The difference between stride length variability (measured by coefficient of variation) in single and dual-task walking will be assessed at baseline, 6 weeks, and 12 weeks
Change from baseline in cognitive function during dual-task test at 6 weeks	Baseline and 6-weeks	Performance on serial subtraction during dual-task walking.