Phase III, Multicenter, Double-blind, Triple-dummy, Randomized, Parallel Clinical Trial to Evaluate the Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 252
- 主要终点
- Total pain relief within four (04) hours after the first PSI administration, assessed using the area under the curve of pain interruption scores (TOTPAR0-4h).
研究概览
简要总结
The purpose of this study is to evaluate the efficacy and safety of DIT112 in adolescents and adults with acute pain after dental surgery for the extraction of impacted third molars.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to confirm voluntary participation and agree with all the purposes of the trial, signing and dating the Free and Informed Consent Form (TCLE) and/or the Free and Informed Assent Form (TALE) in two copies;
- •Age equal to or over 15 years old;
- •Indication of extraction of two (02) impacted third molars, one (01) lower third molar and one (01) upper molar on the same side;
- •Third molar with bone impactions observed through panoramic radiography, with classification by Winter (1926) (1) mesioangular or vertical, and classification according to Pell & Gregory (1933) (2):
- •i. Class II position B; or ii. Class III position A or B
- •Presence of pain of moderate or severe intensity (score greater than or equal to 5 when assessed using an 11-point numeric pain scale) within up to four (04) hours after the end of the surgery.
排除标准
- •Presence of local conditions (lesions in the region of the third molars) that may interfere with the extraction of third molars, such as, but not limited to, pericoronitis, periodontitis, tumors, cysts and inflammation and/or infection in the region to be operated;
- •Presence of any clinical observation finding (clinical/physical assessment) or laboratory condition that is interpreted by the investigating physician as a risk to the research participant's participation in the clinical trial or the presence of uncontrolled chronic disease(s);
- •Presence of a known gastroduodenal ulcer or diagnosis of persistent gastritis;
- •Presence of compromised bone marrow function or diseases of the hematopoietic system;
- •Presence of known severe renal and/or hepatic insufficiency;
- •Diagnosis of epilepsy not adequately controlled;
- •Diagnosis of acute intermittent hepatic porphyria;
- •Presence of known congenital glucose-6-phosphatedehydrogenase deficiency;
- •History of allergy or intolerance to tramadol, diclofenac and pyrazolones (e.g. phenazone, propyphenazone) or pyrazolidines (e.g. phenylbutazone, oxyphenbutazone) including, for example, previous experience of agranulocytosis with one of these substances;
- •Use of sedative, hypnotic or psychotropic medications in the last 24 hours before surgery;
- •Use of anticoagulant medications in the last seven (07) days before surgery;
- •Current chronic treatment with opioids or corticosteroids;
- •Current treatment with selective cyclooxygenase - 2 (COX2) inhibitors;
- •Use of monoamine oxidase inhibitors (MAOIs) such as, but not limited to, phenelzine, tranylcypromine and isocarboxazid, in the last 14 days prior to the day of surgery;
- •Use of any analgesic and/or anti-inflammatory medication in the three (03) days prior to the day of surgery;
- •Known allergy or hypersensitivity to the components of the medicines used during the clinical trial;
- •Surgery to extract third molars lasting more than 60 minutes, considering from the beginning of the incision until the end of the extraction;
- •Technical failure in anesthesia or need to administer more than three tubes of anesthetic for each molar;
- •Presence of temporomandibular joint dysfunction or limited mouth opening;
- •Occurrence of a surgical accident resulting from the extraction of impacted third molars which, in the opinion of the investigator, could interfere with the procedures or evaluations of the trial, such as, but not limited to, intraoperative hemorrhage, probable injury to the inferior alveolar nerve, board fracture bone and soft tissue laceration;
- •Current medical history of cancer and/or cancer treatment in the last 5 years;
- •History of alcohol and/or illicit drug abuse disorder in the last two (02) years;
- •Participants who are pregnant, breastfeeding or planning to become pregnant, or female participants of childbearing potential who are not using a reliable method of contraception;
- •Participation in clinical trial protocols in the last 12 (twelve) months (CNS Resolution 251, of August 7, 1997, item III, subitem J), unless the investigator believes that there may be a direct benefit to the participant.
研究组 & 干预措施
DIT112
The study is triple-dummy. The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet DIT112, oral;
1 capsule tramadol placebo, oral;
1 tablet dipyrone placebo, oral.
干预措施: DIT112 (Drug)
DIT112
The study is triple-dummy. The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet DIT112, oral;
1 capsule tramadol placebo, oral;
1 tablet dipyrone placebo, oral.
干预措施: Dipyrone Placebo (Drug)
DIT112
The study is triple-dummy. The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet DIT112, oral;
1 capsule tramadol placebo, oral;
1 tablet dipyrone placebo, oral.
干预措施: Tramadol Placebo (Drug)
DIPYRONE
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet dipyrone, oral;
1 tablet DIT112 placebo, oral;
1 capsule tramadol placebo, oral.
干预措施: DIPYRONE (Drug)
DIPYRONE
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet dipyrone, oral;
1 tablet DIT112 placebo, oral;
1 capsule tramadol placebo, oral.
干预措施: DIT112 Placebo (Drug)
DIPYRONE
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 tablet dipyrone, oral;
1 tablet DIT112 placebo, oral;
1 capsule tramadol placebo, oral.
干预措施: Tramadol Placebo (Drug)
TRAMADOL
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 capsule tramadol, oral;
1 tablet dipyrone placebo, oral;
1 tablet DIT112 placebo, oral.
干预措施: TRAMADOL (Drug)
TRAMADOL
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 capsule tramadol, oral;
1 tablet dipyrone placebo, oral;
1 tablet DIT112 placebo, oral.
干预措施: DIT112 Placebo (Drug)
TRAMADOL
The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:
1 capsule tramadol, oral;
1 tablet dipyrone placebo, oral;
1 tablet DIT112 placebo, oral.
干预措施: Dipyrone Placebo (Drug)
结局指标
主要结局
Total pain relief within four (04) hours after the first PSI administration, assessed using the area under the curve of pain interruption scores (TOTPAR0-4h).
时间窗: 0-4 hours
(TOTPAR4), with pain relief assessed using a 5-point categorical scale (0 = no relief, 1 = little relief, 2 = some relief, 3 = a lot of relief, 4 = complete relief) at times 0.5, 1, 2, 3 and 4 hours.
次要结局
- Total pain relief within six (06) hours after the first PSI administration, assessed using the area under the curve of pain interruption scores (TOTPAR0-6h).(0-6 hours)
- Use of the rescue medication (time for the first use of the rescue medication within the first 24 hours after the first PSI administration);(24 hours)
- Pain intensity in periods of four (04) and six (06) hours after the first PSI administration, assessed through the difference in pain intensity score (SPID0-4h and SPID0-6h, respectively).(0-4 hours and 0-6 hours, respectively)
- Overall effectiveness of the treatment according to the participant 24 hours after the first administration of the PSI (distribution of participants according to a 5-point categorical scale).(24 hours)