Preoperative predictors of weight loss and improved metabolic health after bariatric surgery

Conditions: Obesity

Registration Number: NL-OMON29250

Lead Sponsor: ederlandse Obesitas Kliniek

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 1299

Inclusion Criteria

?Ability to provide informed consent
?Patient is = 18 and = 75 years old
?BMI = 40 kg/m2 or = 35 kg/m2 with obesity related comorbidity
?Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass or Sleeve Gastrectomy
?Stable weight 3 months prior to inclusion weight (<10% change in body weight for 3 months prior to assessments)

Exclusion Criteria

?Patients who do not understand the patient information letter
?Coagulation disorders
?Type 1 diabetes
?Severe liver disease
?Renal dysfunction
?Pregnancy anticipated in the first two years following surgery
?Use of antibiotics in last 6 months prior to inclusion
?Use of probiotics in last 6 months prior to inclusion

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To validate biomarkers of response to bariatric surgery and to develop algorithms, which combine these variables, to predict individual responses.

Secondary Outcome Measures

Name	Time	Method
-To determine if psychological factors (depression, anxiety, binge eating, eating behavior, food craving, body image, compliance to follow-up) are associated with genetic predisposition and to study how these psychological factors are associated with weight loss, metabolic health and improvement of QoL after bariatric surgery;<br>-To study the difference in cardiorespiratory fitness, muscle strength and physical activity and the relationship of these measurements with weight loss, metabolic health and QoL after bariatric surgery;<br>-To establish predictive (bio)markers of long-term outcomes after bariatric surgery (5-year follow-up). <br><br>In a subgroup of 40 patients, we have additional secondary objectives:<br>-To examine the change of gut hormones and inflammatory markers between 0-3 months after surgery and to evaluate the predictive value of these changes for weight loss and metabolic health 12 months after surgery. <br>