Effect of Ventilation mode on Optic Nerve Sheath Diameter in patients undergoing laparoscopic surgery: A randomised study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- ONSD
研究概览
简要总结
Participants will be randomly allocated to either group V or group P. Monitors will be attached and general anaesthesia will be induced. Mode of ventilation will be kept as per the group allocated. Ventilation will be adjusted to maintain ETCO2 within 35-40 mmHg. ONSD, respiratory parameters, hemodynamics and blood gas parameters will be assessed before induction, 1 and 5 min after intubation, 10, 30 and 60 min after pneumoperitoneum, just before deflation and 5 min after extubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA I and II BMI less than 30 kg per metre square.
排除标准
- •history of eye surgery or known case of eye disease like cataract, glaucoma, uncontrolled cardiovascular, respiratory, renal, liver disease brain tumors, epilepsy or other causes which raise ICP, history of head injury or brain surgery.
结局指标
主要结局
ONSD
时间窗: Before Induction | 1 min after intubation | 5 min after intubation | 10 min after pneumoperitoneum | 30 min after pneumoperitoneum | 60 min after pneumoperitoneum | Just before deflation | 5 min after extubation
次要结局
- Respiratory parameters: Tidal volume, respiratory rate, minute ventilation (MV), EtCO2, Peak pressure (Ppeak), mean airway pressure (Pmean), SpO2(3. Blood gas parameters: PaO2, PaCO2, pH, PaO2/FiO2 ratio)
研究者
Poonam
University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi