Effect of Ventilation mode on Optic Nerve Sheath Diameter in patients undergoing laparoscopic surgery: A randomised study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 56
- Locations
- 1
- Primary Endpoint
- ONSD
Study Overview
Brief Summary
Participants will be randomly allocated to either group V or group P. Monitors will be attached and general anaesthesia will be induced. Mode of ventilation will be kept as per the group allocated. Ventilation will be adjusted to maintain ETCO2 within 35-40 mmHg. ONSD, respiratory parameters, hemodynamics and blood gas parameters will be assessed before induction, 1 and 5 min after intubation, 10, 30 and 60 min after pneumoperitoneum, just before deflation and 5 min after extubation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA I and II BMI less than 30 kg per metre square.
Exclusion Criteria
- •history of eye surgery or known case of eye disease like cataract, glaucoma, uncontrolled cardiovascular, respiratory, renal, liver disease brain tumors, epilepsy or other causes which raise ICP, history of head injury or brain surgery.
Outcomes
Primary Outcomes
ONSD
Time Frame: Before Induction | 1 min after intubation | 5 min after intubation | 10 min after pneumoperitoneum | 30 min after pneumoperitoneum | 60 min after pneumoperitoneum | Just before deflation | 5 min after extubation
Secondary Outcomes
- Respiratory parameters: Tidal volume, respiratory rate, minute ventilation (MV), EtCO2, Peak pressure (Ppeak), mean airway pressure (Pmean), SpO2(3. Blood gas parameters: PaO2, PaCO2, pH, PaO2/FiO2 ratio)
Investigators
Poonam
University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi