Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Endothelial function
研究概览
简要总结
Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.
Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.
详细描述
A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.
Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Educational Counseling Training
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •stable CAD
- •male gender
排除标准
- •insulin-dependent diabetes mellitus
- •significant valvular heart disease
- •exercise-induced myocardial ischemia
- •conditions prohibiting exercise training
结局指标
主要结局
Endothelial function
次要结局
未报告次要终点