Cough suppression therapy as a treatment for patients with cough following a respiratory illness

Not Applicable

• Conditions: Common cold; Infectious respiratory disease; Respiratory - Other respiratory disorders / diseases; Infection - Other infectious diseases

• Registration Number: ACTRN12620000838910
• Lead Sponsor: John Hunter Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-24
• Last Update Posted: 14 September 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

•18 years of age or older.
•Cough between 3 and 6 weeks duration following upper respiratory tract infection
•Cough severity visual analogue scale>39mm
•Non-productive cough
•Probable viral infection as defined by the Common Cold Questionnaire

Exclusion Criteria

1.Primary diagnosis of history of cough secondary to lower airway disease
2.Haemoptysis
3.Productive cough of > 1 table spoon phlegm per day.
4.Cystic fibrosis
5.Bronchiectasis/bronchitis
6.Chronic obstructive pulmonary disease
7.Interstitial lung disease
8.Cognitive impairment, poor English language skills or significant untreated hearing impairment that prevents completion of data collection forms or understanding verbal instructions.
9.Inability to attend study visits.
10.Current smoker or smoker with >20 pack-year smoking history
11.Prominent dyspnoea, especially at rest or at night
12.History of unexplained weight loss
13.Chest pain
14.Current pneumonia
15.Medical concern regarding diagnosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of patients with significant cough. Significant cough is defined as cough severity of 40mm or more on a 100mm visual analogue scale.[26 weeks after randomisation]

Secondary Outcome Measures

Name	Time	Method
Between group differences in change in cough quality of life measured with the Leicester Cough Questionnaire[Baseline, 8, 12 and 26 weeks post onset of cough];Between group differences in cough severity visual analogue scale scores[Baseline, 8, 12 and 26 weeks post onset of cough];Between group differences in change in Vocal Cord Dysfunction Questionnaire scores[Baseline and 8, 12 and 26 weeks post onset of cough];Laryngeal hypersensitivity questionnaire scores[Baseline and 8, 12 and 26 weeks post onset]