NCT06763640Enrolling By Invitation不适用
Prognostic Value of Deep Learning-Derived Tumor-Infiltrating Lymphocyte Percentage in Nasopharyngeal Carcinoma: a Prospective Observational Study
Jiangxi Provincial Cancer Hospital1 个研究点 分布在 1 个国家目标入组 216 人开始时间: 2025年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 216
- 试验地点
- 1
- 主要终点
- Disease Free Survival (DFS)
研究概览
简要总结
Our center plans to conduct a prospective, multicenter, observational study aimed at observing the percentage of TIL infiltration calculated using deep learning methods based on digital pathological images, and analyzing its prognostic significance in nasopharyngeal carcinoma, in order to help guide personalized treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Merge with other malignant tumors
- •Individuals with a history of severe immediate hypersensitivity to any medication used in this study
- •No capacity for civil conduct or limited capacity for civil conduct;
- •Abuse of drugs or alcohol addiction, patients with physical or mental illnesses, and those deemed by the researchers to have a complete or thorough understanding of the possible complications of this study;
- •Other serious acute or chronic medical conditions (including immune-mediated colitis, inflammatory bowel disease, non-infectious pneumonia, pulmonary fibrosis) or mental illnesses (including dementia and epilepsy, recent, past year, or active suicidal ideation or behavior) that may increase the risks associated with the study protocol treatment, or may interfere with the interpretation of study results and (based on the researcher's judgment) make patients unsuitable for participation in this study, or laboratory test abnormalities;
- •Previously diagnosed with immunodeficiency or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related diseases;
- •Pregnant or lactating female patients, male or female patients who have fertility but are unwilling or unable to use contraception for at least one year throughout the study period and after the end of the treatment plan.
结局指标
主要结局
Disease Free Survival (DFS)
时间窗: 3 Years
DFS was defined as the interval from the date of diagnosis to the data of disease recurrence or death
次要结局
- Overall Survival(3 Years)
- Distant Metastasis-free Survival(3 Years)
- Locoregional Recurrenc-free Survival(3 Years)
- Objective Response Rate(During induction chemotherapy (up to 3 months))
研究者
研究点 (1)
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