Two Approaches in Enhancing the Efficacy of Inferior Alveolar Nerve Block During Treatment of Mandibular First Permanent Molars With Symptomatic Irreversible Pulpitis

Not Applicable

• Conditions: Pain, Procedural
• Interventions: Procedure: Cryotherapy

• Registration Number: NCT05427903
• Lead Sponsor: Minia University

Brief Summary

The study is designed as a randomized parallel controlled trial with three groups. Participants aged above 18 years with the first permanent molars with symptomatic signs of irreversible pulpitis will be randomly assigned into 3 groups. The first group (experimental group) will be injected with 4% articaine 1:100.000 epinephrine (inferior alveolar nerve block) will be anesthetized using 4% articaine 1:100.000 plus cryotherapy application, and the second group (experimental group) will be anaesthetised with IANB plus buccal infiltration. For the third group (control group), the mandibular molars will be anaesthetized using epinephrine using the inferior alveolar nerve block.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-04
• Status Verified: 2022-06
• Study First Submitted: 2022-06-16
• Study First Submitted QC: 2022-06-16
• Last Update Submitted: 2022-06-16
• Primary Completion: 2022-06-18
• Study First Posted: 2022-06-22
• Last Update Posted: 2022-06-22
• Study Completion: 2022-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Patients aged above 18 years
• Presence of at least one mandibular first permanent molar, with signs and symptoms of irreversible pulpititis

Exclusion Criteria

• Participants with a history of taking medications that could interfere with the action of the anaesthetic solutions
• Presence of paresthesia
• Presence of psychological problems
• Taking analgesics or other medications that would alter the inflammatory response of the pulp or provide analgesia 12 h pre-operatively

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IANB plus buccal infiltration local anesthesia	Cryotherapy	-
IANB	Cryotherapy	-

Primary Outcome Measures

Name	Time	Method
Pain assessment	up to 24 hours	verbal rating scale (VRS) withh the following scores: Score 0: no pain, Score 1: mild pain, Score 2: moderate pain, and Score 3: severe pain.

Trial Locations

Locations (1)

Minia University; 🇪🇬 Minya, Egypt