The Interaction Between Appetite Hormones

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Other: GLP-1; Dietary Supplement: low calorie diet

• Registration Number: NCT02094183
• Lead Sponsor: University of Copenhagen

Brief Summary

Glucagon Like Peptide (GLP) -1 affects metabolic response corrected for weight change

Detailed Description

Many obese people have had several successful weight losses, however very few can maintain the weight loss over a longer period (e.g. one year) Therefore, we want to investigate the metabolic response and the importance for maintenance of weight loss in obese people, who lost at least 7, 5 % body weight by low calorie diet followed by 52 weeks of diet weight maintenance with or without supplement of GLP-1.

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2014-03-17
• Study First Submitted QC: 2014-03-20
• Study First Posted: 2014-03-21
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Status Verified: 2014-07
• Last Update Submitted: 2014-07-04
• Last Update Posted: 2014-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• BMI > 30 and < 40 (kg/m2)
• Healthy

Exclusion Criteria

• Other known illness
• Medicine that affects glucose- and lipid metabolism, appetite or food intake
• Pregnancy
• Breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
GLP-1	GLP-1	GLP-1 and low calorie diet
GLP-1	low calorie diet	GLP-1 and low calorie diet
Control	low calorie diet	low calorie diet

Primary Outcome Measures

Name	Time	Method
Change in hormone level corrected for weight change	Baseline and week 52

Trial Locations

Locations (2)

University of Copenhagen; 🇩🇰 Copenhagen, Denmark

Hvidovre University Hospital; 🇩🇰 Hvidovre, Denmark