Plasma ropivacaine concentrations and duration of sensory block after ultrasound-guided transversus abdominis plane block, with and without additives (adrenaline and clonidine), for gynaecological surgery
Phase 3
Completed
- Conditions
- Post operative painAnaesthesiology - Pain management
- Registration Number
- ACTRN12614000587606
- Lead Sponsor
- Royal Prince Alfred Hospital, Sydney Local Health District
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
Adult female patients, aged 18 to 65, undergoing elective gynaecological surgery and who are planned to receive TAP blocks
Exclusion Criteria
Allergy to any of the drugs in the study, morbid obesity, infection at site of block placement, pre-existing neurological or muscular disease, coagulopathy, significant liver or renal disease, and pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma ropivacaine levels as measured by Gas Chromatograph Mass Spectrometry following transversus abdominis plane block[Time points following transversus abdominis plane block: every 10 minutes for the first hour, then every 30 minutes until 3 hours post block, and then at 6, 9, and 12 hours post block]
- Secondary Outcome Measures
Name Time Method Sensory testing (warm, cold, and Von Frey Filament testing)[3, 6, 9, and 12 hours post block]