Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 2,800
- 试验地点
- 1
- 主要终点
- Distribution and prevalence of elevated Lipoprotein(a)
研究概览
简要总结
The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.
详细描述
The objective of this study is to investigate the prevalence of elevated lipoprotein(a) concentrations and distribution of lipoprotein(a) in a working general population. This is a prospective study investigating the association of lipoprotein(a) with cardiovascular markers and outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any healthcare workers working in healthcare settings (regardless of PHI and/or private setting) aged 21 and above OR family member such as father, mother, siblings, grandparents, spouse and children aged 12 and above of recruited staff with high Lpa ≥120nmol/l
- •Study team members can also be recruited because we are trying to find the prevalence of elevated Lp(a)
排除标准
- •Inability to provide informed consent.
- •Pregnant women.
研究组 & 干预措施
Working General Population
Consenting hospital staff are recruited to this study. Blood test and questionnaires are taken at baseline. Prospective follow-up of cardiovascular events are undertaken.
结局指标
主要结局
Distribution and prevalence of elevated Lipoprotein(a)
时间窗: 3 years
Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities.
次要结局
- Correlation of lipoprotein(a) with cardiovascular outcomes(10 years)
- Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events(10 years)
研究者
Loh Wann Jia
Primary Investigator and Consultant Endocrinologist.
Changi General Hospital