Aqueous Urea Concentration May be Related to Cataract Development
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cataract Cortical
- Sponsor
- Assiut University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Blood urea level
- Last Updated
- 8 years ago
Overview
Brief Summary
cataracts could be cured with eye drops. Some studies reported that in chronic renal failure, the occurrence of cataract is rare and the mechanism is unknown. The aim of this research is to describe correlation between urea concentration in the serum and aqueous humor and development of age related cataract.
Detailed Description
The study was conducted in the departments of Ophthalmology and internal medicine, Asyut University hospitals, Egypt. Three groups of subjects were included: patients with age related cortical cataracts who are otherwise healthy (cases) and two control groups; first systemically healthy subjects with ocular problems other than cataract and a second control group of patients with impaired renal functions and are not on dialysis treatment and thus have elevated serum urea levels. Slit lamp examination was performed to evaluate crystalline lens for opacities. Measurement of serum urea was done for all study subjects. Aqueous humor urea concentration was done only for the group of patients who are planned to have intraocular surgery. For that purpose, 0.1 ml of aqueous humor will be aspirated at the start of routine intraocular surgery.
Investigators
Hassan Lotfy Fahmy
Clinical Professor
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Senile Cortical cataract.
Exclusion Criteria
- •Senile Nuclear cataract.
- •Congenital cataract
- •Traumatic cataract
Outcomes
Primary Outcomes
Blood urea level
Time Frame: 1 Day
The relation between blood urea level and cataract