Aqueous Urea Concentration May be Related to Cataract Development

Brief Summary: cataracts could be cured with eye drops. Some studies reported that in chronic renal failure, the occurrence of cataract is rare and the mechanism is unknown. The aim of this research is to describe correlation between urea concentration in the serum and aqueous humor and development of age related cataract.

Detailed Description: The study was conducted in the departments of Ophthalmology and internal medicine,

Asyut University hospitals, Egypt. Three groups of subjects were included:

patients with age related cortical cataracts who are otherwise healthy (cases) and two control groups; first systemically healthy subjects with ocular problems other than cataract and a second control group of patients with impaired renal functions and are not on dialysis treatment and thus have elevated serum urea levels. Slit lamp examination was performed to evaluate crystalline lens for opacities. Measurement of serum urea was done for all study subjects. Aqueous humor urea concentration was done only for the group of patients who are planned to have intraocular surgery. For that purpose, 0.1 ml of aqueous humor will be aspirated at the start of routine intraocular surgery.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
cortical cataract	cortical cataract	patients with age related cortical cataracts who are otherwise healthy
ocular problems	cortical cataract	systemically healthy subjects with ocular problems other than cataract
impaired renal functions	cortical cataract	patients with impaired renal functions and are not on dialysis

Primary Outcome Measures

Name	Time	Method
Blood urea level	1 Day	The relation between blood urea level and cataract

Secondary Outcome Measures

Name	Time	Method

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