The Prevalence of Influenza Related Invasive Aspergillosis in Swedish Intensive Care Units
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 55
- 试验地点
- 10
- 主要终点
- Prevalence of proven or probable invasive pulmonary aspergillosis
研究概览
简要总结
This is a multicenter study with the aim to determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units and to assess the clinical impact of and risk factors for influenza-related invasive pulmonary aspergillosis
详细描述
This is a multicenter prospective observational study conducted at 12 intensive care units (ICU) in Sweden. All patients >18 years of age with a Polymerase Chain Reaction (PCR)-verified influenza A or B diagnosed up to 7 days before admission to the ICU or during ICU care, will be included in the study.
A new clinical routine has been implemented at the study centers: During the ICU stay screening with Beta-D-glucan and Galactomannan in blood/serum will be performed twice weekly and a respiratory sample will be retrieved for fungal culture and microscopy once weekly.
All results from collected samples will be available to the patient's attending physicians. Clinical and microbiological data will be collected, and the diagnosis of invasive aspergillosis will be made using predefined diagnostic criteria.
Objectives:
- To determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units
- To assess the clinical impact of and risk factors for influenza-related invasive pulmonary aspergillosis
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed influenza A or B diagnosed up to 7 days before ICU admission, or during ICU care
- •Admitted to the ICU
排除标准
- •Under 18 years of age
结局指标
主要结局
Prevalence of proven or probable invasive pulmonary aspergillosis
时间窗: From date of enrollment up to 90 days after enrollment
Enrolled patients will be categorized as proven or probable invasive pulmonary aspergillosis at discharge from the ICU.
次要结局
- Sequential Organ Failure assessment Score (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Use of mechanical ventilation (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Use of non-invasive ventilation (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Use of vasopressor (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Use of renal replacement therapy (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Acute Respiratory Distress Syndrome (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- Days of ICU stay (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- ICU mortality (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of admission to ICU to date of discharge from ICU, approximately 21 days)
- 90-day mortality after ICU admission (in patients diagnosed with proven/probable invasive pulmonary aspergillosis and those that were not)(from date of ICU admission to 90 days after ICU admission)
研究者
Anders Krifors
Principal Investigator
Karolinska University Hospital