Distinction Between Lung Cancer and Gynecological Cancers by Canine Scent Detection

Phase 2

Terminated

• Conditions: Lung Cancer; Breast Cancer; Ovarian Cancer
• Interventions: Other: exhalation analysis of breath sample

• Registration Number: NCT01383408
• Lead Sponsor: Schillerhoehe Hospital

Brief Summary

Previous studies have shown that specially trained sniffer dogs are capable to discriminate breath samples of patients with lung cancer and healthy individuals. So far it is not known whether this differentiation is specific for lung cancer or just identifies any form of (solid) tumor. Therefore, the dog's ability to differentiate between lung cancer, breast cancer and ovarian cancer is tested.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Study First Submitted: 2011-06-24
• Study First Submitted QC: 2011-06-27
• Study First Posted: 2011-06-28
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Status Verified: 2013-05
• Last Update Submitted: 2013-05-05
• Last Update Posted: 2013-05-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 752

Inclusion Criteria

• histologically confirmed lung or breast or ovarian cancer

Exclusion Criteria

• other cancers
• previous medical intervention within the last 14 days before gathering of the breath sample

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
healthy individual	exhalation analysis of breath sample	healthy individual with no lung disease and no history of cancer including lung cancer
lung cancer	exhalation analysis of breath sample	patients with histologically confirmed lung cancer, but no history of other cancer
breast cancer	exhalation analysis of breath sample	patients with histologically confirmed breast cancer, but no history of other cancer
ovarian cancer	exhalation analysis of breath sample	patients with histologically confirmed ovarian cancer, but no history of other cancer

Primary Outcome Measures

Name	Time	Method
Specificity for Lung Cancer	breath samples will be tested within 40 days after gathering	exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with lung cancer from those of patients with other (tested) cancers

Secondary Outcome Measures

Name	Time	Method
Discriminability of breast and ovarian cancer	breath samples will be tested within 40 days after gathering	exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with breast cancer from those of patients with other ovarian cancer

Trial Locations

Locations (2)

Robert Bosch Hospital; 🇩🇪 Stuttgart, Baden-Württemberg, Germany

Schillerhoehe Hospital; 🇩🇪 Gerlingen, Baden-Württemberg, Germany