Risk of Allergic Asthma Occurring in the Long Term From an Episode of Acute Bronchiolitis in Infants: Clinical, Allergological and Functional Evaluation in the Long Term
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 320
- 试验地点
- 2
- 主要终点
- Risk factors for asthma 6 years after an episode of acute bronchiolitis
研究概览
简要总结
Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult.
Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated at home, from the epidemic seasons of 2011-2012 and 2015-2017 to know their respiratory evolution, especially if they developed allergen sensitization and / or asthma.
详细描述
Follow-up consultation 6 years after an episode of acute bronchiolitis at Clermont-Ferrand hospital with:
- Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking;
- Physical examination ;
- Evaluation of precariousness during the same interview with the EPICES questionnaire;
- Prick tests with positive control (histamine) and negative (physiological saline) and prick for the main pneumallergens (mites, alternaria, grasses, cat and dog) and trophallergens (egg, milk, fish, soy, wheat, peanut);
- Blood test with blood count, determination of specific IgE (5 pneumallergens and 5 trophallergens), dosage of sRAGE;
- Fonctionnal respiratory test with reversibility test
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
盲法说明
no masking
入排标准
- 年龄范围
- 7 Years 至 9 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute bronchiolitis in an infant less than one year old, included in studies KL6 (winter period 2011-2012) or CC16 (winter period 2015-2016) at clermont-ferrand hospital.
排除标准
- •Bronchopulmonary dysplasia;
- •History of prematurity <34 AS;
- •Mucoviscidosis;
- •known immune deficiencies;
- •Primary ciliary dyskinesia suspected;
- •Congenital heart disease;
- •Acute renal failure.
- •Refusal of parents to participate
研究组 & 干预措施
group 1
cohorts of infants with acute bronchiolitis
干预措施: Pneumological evaluation (Diagnostic Test)
结局指标
主要结局
Risk factors for asthma 6 years after an episode of acute bronchiolitis
时间窗: at 6 years
Presence / absence of asthma 6-9 years after an episode of bronchiolitis during the first year of life The diagnosis of asthma is established during a consultation by a pneumopediatrician on the following criteria: * ≥3 documented respiratory symptoms ≥ 2 times; * Or an episode lasting ≥ 4 weeks; * With symptoms: tachypnea, wheezing, expiratory stridor, signs of chest retraction or wheezing diagnosed by a doctor.
次要结局
- Correlation between onset of asthma and severity of bronchiolitis(at 6 years)
- relationship between sRAGE serum markers and the occurrence of longer-term asthma(at 6 years)
- relationship between KL-6 serum markers and the occurrence of longer-term asthma(at 6 years)
- relationship between CC16 serum markers and the occurrence of longer-term asthma(at 6 years)