Does metabolomic incompatibility between living liver donors and recipients predict early allograft dysfunction in liver transplantation?

Not Applicable

Completed

• Conditions: liver transplantation; Early allograft dysfunction; Metabolomic incompatibilty between donors and recipients; Metabolic and Endocrine - Other metabolic disorders; Surgery - Other surgery; Cancer - Liver

• Registration Number: ACTRN12615000446561
• Lead Sponsor: Dr. Huang-Ping Yu

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-08
• Study Completion: 2018-04-24
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

Inclusion criteria for donor:
1.No history of liver disease
2.No medical history of cancer in the last 10 years
3.No HBsAg, no hepatitis C virus or HIV antibodies

Inclusion criteria for recipient:
1.Patients with liver cirrhosis or hepatocellular carcinoma in need for liver transplantation

Exclusion Criteria

Exclusion criteria for donor:
1.Refusal to sign informed consent
2.Age <20 years old
Exclusion criterial for recipient:
1.Refusal to sign informed consent
2.Recent sepsis or shock status
3.History of hepatoencephalopathy
4.History of hepatorenal syndrome
5.Anticipated pulmonary hypertension with preoperative pulmonary wedge pressure >35mmHg

Study & Design

• Study Type: Observational
• Study Design: Not specified