Tissue Oxygen Index and Pulsatility Index in Orthopedic Surgery: a NIRS and TCD Pilot Trial
Completed
- Conditions
- Cerebral Microemboli
- Registration Number
- NCT02340416
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Cerebral microemboli (ME) are frequently generated during major orthopaedic surgery. The primary objective of this study was applying novel transcranial Doppler (TCD) ultrasound software algorithm to quantify (ME load/15 minutes) and qualify (particulate vs. gaseous) ME, detected as high-intensity transient signals (HITS) in both middle cerebral arteries (MCAs) before and after orthopaedic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- hip prosthesis
- knee prosthesis
- shoulder prosthesis
- spine surgery
Exclusion Criteria
- severe valvular heart defect
- acute neurological disorder
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral microemboli detection prior and directly after surgery
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie cerebral microemboli formation during orthopedic surgery as studied in NCT02340416?
How does the novel TCD algorithm in NCT02340416 compare to standard methods for quantifying particulate vs. gaseous microemboli in orthopedic patients?
Are specific biomarkers associated with high-intensity transient signals (HITS) in middle cerebral arteries (MCAs) during orthopedic procedures?
What adverse events are linked to cerebral microemboli detection using transcranial Doppler (TCD) and near-infrared spectroscopy (NIRS) in orthopedic surgery?
What pharmacological agents or combination therapies are being explored to mitigate microemboli-related cerebral hypoxia in orthopedic surgery patients?
Trial Locations
- Locations (1)
Dept. of Anaesthesiology & Intensive Care, Vienna General Hospital, Medical University of Vienna
🇦🇹Vienna, Austria