Evaluation of the Effects of Laughter Yoga on Pain Intensity, Stress, and Beta-endorphin Levels in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Change in pain intensity measured by Visual Analog Scale (VAS) at [time point]
研究概览
简要总结
This randomized controlled study aims to evaluate the effects of laughter yoga on pain intensity, fatigue, and beta-endorphin levels in patients with Multiple Sclerosis. Laughter yoga, a complementary therapy combining breathing exercises and laughter techniques, may help improve symptom management and psychological well-being in individuals with MS.
详细描述
Multiple Sclerosis (MS) is a chronic, autoimmune, and demyelinating disease that generally affects the central nervous system in young adults. Multiple Sclerosis is a highly heterogeneous disease, with a wide range of clinical signs and symptoms depending on the area of the central nervous system affected, including motor, sensory, autonomic, and cognitive impairments. Multiple Sclerosis is associated with a broad spectrum of bodily dysfunctions, including motor problems such as muscle weakness, changes in muscle tone, ataxia, abnormal balance, and sensory disturbances. In addition, fatigue, pain, bladder and bowel dysfunction, cognitive and emotional problems, vision problems, speech and swallowing disorders, and sexual dysfunction also affect individuals with MS. Currently, there are 2.5 million MS patients worldwide, and the cost of treatment and care for these patients is quite high.
In addition to medical treatment, traditional and complementary medicine (TCM) methods are used in the treatment of pain and fatigue. Laughter Yoga, a type of yoga that has begun to be applied as a TCM method, was developed by Indian physician Dr. Developed by Madan Kataria in 1995, each laughter yoga session consists of breathing exercises, stretching and relaxation techniques, and laughter exercises. Physiologically, laughter yoga has been reported to increase breathing, relax muscles, stimulate circulation and the immune system, increase endorphin release, thereby increasing pain threshold and tolerance, reduce fatigue, decrease stress hormone levels, strengthen mental function, reduce depression and anxiety, improve sleep quality, and enhance interpersonal relationships and social interaction, thus improving psychological well-being. This research was planned as a randomized controlled experimental study to evaluate the effects of laughter yoga applied to Multiple Sclerosis patients on pain intensity, fatigue, and Beta Endorphin levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Being over 18 years old
- •Being able to communicate adequately
- •Volunteering to participate in the research
排除标准
- •Unwillingness to participate in the study
- •Having severe cognitive impairment that prevents understanding or participation in the intervention
- •Having a psychiatric disorder that may affect participation in the study
- •Experiencing an acute MS relapse during the study period
- •Having another serious neurological or chronic disease that may affect the study outcomes
- •Regular participation in another complementary therapy program similar to laughter yoga
- •Communication problems that prevent participation in the intervention sessions
研究组 & 干预措施
Experimental Group
Patients with Multiple Sclerosis who will receive laughter yoga in addition to routine care.
干预措施: Laughter Yoga (Behavioral)
Control Group
Patients with Multiple Sclerosis who will receive routine care without laughter yoga.
结局指标
主要结局
Change in pain intensity measured by Visual Analog Scale (VAS) at [time point]
时间窗: Baseline and week 4
Pain intensity will be assessed using the Visual Analog Scale (VAS), a 10 cm scale ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will indicate their pain level by marking on the scale, and the score will be determined by measuring the distance in centimeters or millimeters.
次要结局
- Fatigue Level(1 month)
- Change in plasma beta-endorphin levels measured by ELISA at baseline and week 4(Baseline and week 4)
研究者
Gul Dural
Assistant professor
Firat University