Research of Predictive Factors of Weight Loss After Pharmacological or Surgical Treatment in Patients Suffering From Obesity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Correlation between weight loss after surgery and clinical, neuropsychological and biological parameters.
研究概览
简要总结
As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 65 years
- •Obesity, with bariatric surgery indicated after a multidisciplinary evaluation in case of surgical treatment.
- •Good physical and mental health, enabling informed consent.
- •French speaker
排除标准
- •Legal protection
- •Pregnancy or breastfeeding
- •History of bariatric surgery (except gastric banding, provided it was removed more than five years ago).
- •Acute or progressive chronic disease
- •Alcohol consumption of more than 20 g/day
- •Inflammatory bowel disease;
- •Digestive autonomic diabetic neuropathy.
- •Consumption of dietary supplements (stanols, probiotics, prebiotics or omega-3).
- •Following a vegan or gluten-free diet or being lactose intolerant.
- •Fibre consumption >30 g/day
- •Recent change in antidiabetic medication within the past 3 months.
结局指标
主要结局
Correlation between weight loss after surgery and clinical, neuropsychological and biological parameters.
时间窗: Throughout the entire study, aproximately during 5 years
The percentage of excessive weight loss after bariatric surgery will be correlated with * Clinical parameters (Binge Eating Scale and modified Yale Food Addiction Scale 2.0) * Neuropsychological parameter (Barratt Impulsivness Scale and Trail Making Test) * Biological parameters
次要结局
- Binge Eating Disorder.(Throughout the entire study, aproximately during 5 years)
- Food Addiction.(Throughout the entire study, aproximately during 5 years)
- Eating attitudes(Throughout the entire study, aproximately during 5 years)
- Cognitive flexibility.(Throughout the entire study, aproximately during 5 years)
- Impulsivity.(Throughout the entire study, aproximately during 5 years)
- Self-reported quality of life.(Throughout the entire study, aproximately during 5 years)
- Obesity.(Throughout the entire study, aproximately during 5 years)
- Physical activity.(Throughout the entire study, aproximately during 5 years)
- Food intake.(Throughout the entire study, aproximately during 5 years)
- Blood samples(Throughout the entire study, aproximately during 5 years)
- Fecal sample(Throughout the entire study, aproximately during 5 years)