ITMCTR2000003889招募中未知
The diagnostic significance of quantitative chest CT emphysema index and emphysema distribution type for asthma-copd overlap (ACO)
Gansu Provincial Hospital of TCM0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational study
入排标准
- 年龄范围
- 18 至 80（—）
- 性别
- All
入选标准
- •Asthma group: Patients with stable asthma according to gina2017 diagnostic criteria were included;
- •1. The symptoms such as wheezing, shortness of breath, chest tightness, cough and other symptoms recur clearly, which are related to exposure to cold air, physical and chemical stimulation, upper respiratory tract infection and exercise. The intensity changes with time, and can be relieved by antiasthmatic drugs or by itself.
- •2. Definite reversibility of airflow restriction: positive bronchodilation test (fevl. 0 improved more than 200 ml and more than 12%) after inhalation of bronchodilator drugs;
- •3. Asthma patients with fixed airflow limitation were also included in the asthma group (FEV1.0 / FVC < 0.7).
- •COPD group: stable COPD patients meeting gold 2013 diagnostic criteria were included.
- •1. FEV1.0 / FVC < 0.7 after bronchodilation test;
- •2. Smoking history is more than 10 pack years or have a clear history of harmful smoke exposure;
- •3. Chronic cough, expectoration, asthma and other respiratory symptoms;
- •4. Patients with previous asthma or recurrent wheezing were excluded.
- •Normal control group: healthy non-smokers were included.
- •1. No smoking history;
- •2. No history of chronic or severe respiratory diseases, no respiratory symptoms;
- •3. The pulmonary ventilation function was normal (FEV1.0 / FVC > 0.7 and greater than 92% of the predicted value; FEV1.0 and FVC were greater than 80% of the predicted value, and the shape of flow volume curve was normal;
- •4. Chest CT examination showed no structural lesions, no pulmonary nodules or masses larger than LCM.
排除标准
- •1. Patients with acute exacerbation within 6 weeks;
- •2. Chest CT showed that the diameter of lung mass was larger than 3cm;
- •3. Patients with other severe respiratory diseases, such as extensive bronchiectasis, interstitial lung disease, lung cancer, infectious lung disease, massive pleural effusion, etc;
- •4. Patients with history of chest trauma or surgery;
- •5. Patients with other serious diseases: heart failure, severe liver and kidney dysfunction, severe anemia, mental disorders, etc.
- •6. Patients who cannot cooperate with history collection, pulmonary function or chest CT examination.
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