ITMCTR2000003889
Recruiting
未知
The diagnostic significance of quantitative chest CT emphysema index and emphysema distribution type for asthma-copd overlap (ACO)
Gansu Provincial Hospital of TCM0 sitesTBD
ConditionsAsthma-COPD Overlap, ACO
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Asthma-COPD Overlap, ACO
- Sponsor
- Gansu Provincial Hospital of TCM
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Asthma group: Patients with stable asthma according to gina2017 diagnostic criteria were included;
- •1\. The symptoms such as wheezing, shortness of breath, chest tightness, cough and other symptoms recur clearly, which are related to exposure to cold air, physical and chemical stimulation, upper respiratory tract infection and exercise. The intensity changes with time, and can be relieved by antiasthmatic drugs or by itself.
- •2\. Definite reversibility of airflow restriction: positive bronchodilation test (fevl. 0 improved more than 200 ml and more than 12%) after inhalation of bronchodilator drugs;
- •3\. Asthma patients with fixed airflow limitation were also included in the asthma group (FEV1\.0 / FVC \< 0\.7\).
- •COPD group: stable COPD patients meeting gold 2013 diagnostic criteria were included.
- •1\. FEV1\.0 / FVC \< 0\.7 after bronchodilation test;
- •2\. Smoking history is more than 10 pack years or have a clear history of harmful smoke exposure;
- •3\. Chronic cough, expectoration, asthma and other respiratory symptoms;
- •4\. Patients with previous asthma or recurrent wheezing were excluded.
- •Normal control group: healthy non\-smokers were included.
Exclusion Criteria
- •1\. Patients with acute exacerbation within 6 weeks;
- •2\. Chest CT showed that the diameter of lung mass was larger than 3cm;
- •3\. Patients with other severe respiratory diseases, such as extensive bronchiectasis, interstitial lung disease, lung cancer, infectious lung disease, massive pleural effusion, etc;
- •4\. Patients with history of chest trauma or surgery;
- •5\. Patients with other serious diseases: heart failure, severe liver and kidney dysfunction, severe anemia, mental disorders, etc.
- •6\. Patients who cannot cooperate with history collection, pulmonary function or chest CT examination.
Outcomes
Primary Outcomes
Not specified
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