Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Not Applicable

Completed

• Conditions: Critical Illness; Copd; Trauma; Shock; Pulmonary Embolism; Ventilation Perfusion Mismatch
• Interventions: Diagnostic Test: EtCO2; Diagnostic Test: PaCO2

• Registration Number: NCT05341258
• Lead Sponsor: Gaziosmanpasa Research and Education Hospital

Brief Summary

Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-11
• Study Start: 2022-01-01
• Study First Submitted: 2022-04-17
• Study First Submitted QC: 2022-04-17
• Study First Posted: 2022-04-22
• Primary Completion: 2022-08-01
• Study Completion: 2022-08-01
• Last Update Submitted: 2022-08-22
• Last Update Posted: 2022-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Critical Care Patients intubated in last 24 hours.

Exclusion Criteria

• Patients younger than 18 years old.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Critical Care Patients whom intubated last 24 hours	PaCO2	Critical Care Patients whom intubated last 24 hours
Critical Care Patients whom intubated last 24 hours	EtCO2	Critical Care Patients whom intubated last 24 hours

Primary Outcome Measures

Name	Time	Method
Mortality	6 months	Evaluation of correlation between PaCO2 and ETCO2 gradient difference and mortality in intubated critical care patients and mortality rates

Secondary Outcome Measures

Name	Time	Method
Ventilator Free Days	6 months	Days during which the patient was mechanically ventilated
ICU Length of Stay	6 months	Days patients treated at ICU

Trial Locations

Locations (1)

Gaziosmanpasa Training Research Hospital; 🇹🇷 Istanbul, Turkey