Assessment of viruddha ahara in autoimmune diseases (plaque psoriasis, vitiligo, and rheumatoid arthritis) and its association with biomarkers (AGE & HsCRP) - a case control study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 558
- 试验地点
- 1
- 主要终点
- Association of viruddha ahara practices in autoimmune disease patients (plaque psoriasis, vitiligo, and rheumatoid arthritis) and healthy controls.
研究概览
简要总结
In Ayurvedic texts, different Aacharyas have mentioned that such type of incompatible food combination is origin of various ailments like for example Aacharya Charaka and Aacharya Madhav have described Viruddha Ahara as cause of Kustha Rogas (skin diseases) and Aamvata (Rheumatoid arthritis).
Various studies have suggested that skin diseases like Plaque Psoriasis, Vitiligo and joint disease like Rheumatoid arthritis are autoimmune disease. But, exact cause of autoimmune diseases is not fully understood. Various factors like genetic predisposition, environmental factors and life style, can play a role in their development. In Ayurveda texts, Nidana Parivarjana is one of the described treatments of diseases. Hence, Nidana Seven may be triggering some factors in body responsible for autoimmune disease pathogenesis. But the specific factors that are triggering this immune response in healthy individuals are still not fully understood. But, to the best possible knowledge there is limited study specifically linking role of Viruddha Ahara in etiopathogenesis of autoimmune disease and role of Viruddha Ahara in alteration of biomarker in diseased patient of autoimmune disease and healthy controls. Hence, it is crucial to conduct research aiming to establish relation between autoimmune diseases and Viruddha Ahara.
The goal of the current study is to asses Viruddha Ahara practices in both healthy controls and patients with three autoimmune diseases that is Plaque psoriasis, Vitiligo, and Rheumatoid arthritis, to observe for any common pattern in the three autoimmune diseases. Additionally, to evaluate how Viruddha Ahara affects gene expression, disease severity scale, and biomarker levels in autoimmune disease patients and healthy controls will also be studied.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 21.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •For cases
- •Patients of RA or Plaque psoriasis or vitiligo as per the diagnostic criteria, with chronicity less than 10 years, within the age Group of 21 to 45 years.
- •Patients of either gender, religion, occupation or socio-economic status.
- •Patients willing to participate in the study with written informed consent.
- •For control Apparently healthy individuals between the age group of 21 to 45 years, fulfilling the Criteria of Swasthya Assessment Scale and willing to provide written informed consent in the study.
- •Definitions Apparently healthy means Individuals have no history of any systemic or infective diseases since the last 1 month, have no complaints of any weakness and demonstrate high working ability.
排除标准
- •Patient who are taking anti inflammatory (analgesics), steroids, disease-modifying antirheumatic drugs (dmards), uv therapy, or other potential drugs which may affect the disease outcome and hamper assessment.
- •Patient having any other type of arthropathy such as neoplasm of spine, gout, ankylosing spondylitis, and other existing skin disorder
- •Patient with any other systemic disorders like paralysis, cancer, renal failure, hepatic failure, cardiac disease, tuberculosis, diabetes mellitus, psychiatric illness, hypertension, hypo, and hyperthyroidism.
- •Pregnant women and lactating mothers.
- •Patient taking antibiotic therapy for any systemic illness within 2 months.
- •Patients with crippling bone deformity.
结局指标
主要结局
Association of viruddha ahara practices in autoimmune disease patients (plaque psoriasis, vitiligo, and rheumatoid arthritis) and healthy controls.
时间窗: 1.5 year
次要结局
- 1. Characterization of viruddha ahara practices in individuals diagnosed with plaque psoriasis, vitiligo, & rheumatoid arthritis, as well as in healthy controls.(2. Assessment of the impact of viruddha ahara on disease severity scales (pasi, vetf, das28) in plaque psoriasis, vitiligo, & rheumatoid arthritis patients.)
研究者
Dr Rupashri Nath
All India Institute Of Ayurveda, New Delhi