Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- Population Health Research Institute
- Enrollment
- 18000
- Primary Endpoint
- Occurrence of Cardiovascular death
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
During primary percutaneous coronary intervention, distal embolization of thrombus and impaired microvascular perfusion has been associated with an increased mortality. Thrombectomy devices during primary percutaneous coronary intervention may prevent distal embolization by reducing thrombus burden and thus improve microvascular perfusion and reduce mortality.
Detailed Description
An individual patient meta-analysis of large randomized controlled trials comparing manual thrombectomy versus percutaneous coronary intervention alone in patients with ST elevation myocardial infarction will provide significantly more power to detect differences in mortality as well as important but rare events such as stroke and to assess benefits in pre-defined subgroups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Randomized controlled trials comparing manual thrombectomy vs. percutaneous coronary intervention alone in patients with ST elevation myocardial infarction published between January 1980 and April
- •Large trials randomizing more than 1000 patients.
- •Trials must have had at least 30 day follow up.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Occurrence of Cardiovascular death
Time Frame: up to 30 days
time to event analysis
Secondary Outcomes
- Occurrence of Cardiovascular death(up to 180 days)