Robotic-assisted radical prostatectomy in steep Trendelenburg position - cerebral perfusion and oxygenation in patients with impaired cerebral autoregulation and risk of postoperative cognitive deficits

• Conditions: F06.7; F05.8; Mild cognitive disorder; Other delirium

• Registration Number: DRKS00010014
• Lead Sponsor: niversitätsklinikum Hamburg-Eppendorf,Klinik für Anästhesiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-21
• Study Completion: 2017-05-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 414

Inclusion Criteria

>18 years, ASA classification I-IV, written informed consent, excellent (German) language skills in order to undergo the neuropsychological testing

Exclusion Criteria

history of cerebrovascular disease, intracranial pathology, dementia, ASA >=V (American Society of Anesthesiology physical status classification system)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Cerebral autoregulation (cerebral oxygenation index, intraoperative measurement), 2) postoperative cognitive dysfunction (pre- and postoperative assessment: California Verbal Learning Test, grooved pegboard test, Trail Making Test A/B, digit span test)

Secondary Outcome Measures

Name	Time	Method
postoperative delirium (CAM-ICU),<br>self-assessed cognitive function,<br>blood pressure variability,<br>hemodynamic parameters