Prevalence of Helicobacter Pylori Infection and Gastric Cancer in the West Indies

Not yet recruiting

• Conditions: Gastric Neoplasms; Stomach Neoplasms; Helicobacter Pylori
• Interventions: Biological: Helicobacter Pylori detection

• Registration Number: NCT04949737
• Lead Sponsor: University Hospital Center of Martinique

Brief Summary

Estimating the prevalence of Helicobacter Pylori infection in newly diagnosed stomach cancers in the West-Indies will help to understand the epidemiology of this cancer, which is over-incident in the West Indies compared to France. In addition, the constitution of a biobank (tumor tissues, healthy tissues and serum) will allow to set up in a second time etiological studies to identify other risk factors in particular in connection with the exposure to environmental pollutants to adapt the prevention measures.

Detailed Description

In the Antilles-Guyana, gastric cancer affects approximately 80 men and women each year in Guadeloupe and Martinique, and 20 in French Guiana. It is more frequent than in France and represents 4.5% of cancers in men in Martinique, 5.3% in Guadeloupe and 5.7% in French Guyana. It is the 3rd most common cancer site in men in Guadeloupe and Martinique, and the 4th in French Guiana. In women, it is the 3rd most frequent cancer in Martinique and the 4th in Guadeloupe, whereas it is less frequent in French Guiana.

Studies are needed to estimate this prevalence in the general population and in cancer patients. The prevalence of Helicobacter pylori infection is not well known in the general population in the Caribbean and when gastric cancer is diagnosed, the bacterium is rarely tested.

Dietary habits in our regions are characterized by a high consumption of salt (salted), meat and smoked fish. These dietary habits, common to some Southeast Asian countries, could partly explain the high incidence of stomach cancer observed. But environmental risk factors could also be involved.

Patients referred to gastroenterology with a suspected endoscopic diagnosis of gastric cancer will be offered to participate in the study after the fibroscopy has been performed and their consent will be obtained for the use of diagnostic specimen remains for research purposes.

Study Timeline

• Study First Submitted: 2021-06-16
• Study First Submitted QC: 2021-06-30
• Study First Posted: 2021-07-02
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-11
• Last Update Posted: 2025-02-13
• Study Start: 2025-04
• Primary Completion: 2028-04
• Study Completion: 2028-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

1. Patient over 18 years of age, residing for at least 6 months in Martinique, with a primary diagnosis of gastric cancer
2. Patient having read the information note and having signed the consent to participate in the study
3. Patient with social security coverage

Exclusion Criteria

1. Refusal to participate
2. Patient who could not answer the questionnaires
3. Patient not affiliated to a social security system
4. Patient not fluent in French
5. Patient under legal protection (legal protection, guardianship, curators, etc.)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Helicobacter Pylori detection	Helicobacter Pylori detection	Systematic biopsies of the tumor and the gastric cavity will be performed during the initial fibroscopy in accordance with the recommendations of the French Society of Digestive Endoscopy (SFED).

Primary Outcome Measures

Name	Time	Method
Estimation of the prevalence of Helicobacter pylori	At baseline	Helicobacter Pylori has detected by immunohistochemistry in the stomach of patients with gastric cancer.

Trial Locations

Locations (1)

CHU Martinique; 🇲🇶 Fort-de-France, Martinique