GENome-based therapeutic drugs for DEPressio

Not Applicable

Completed

• Conditions: Major depressive episode; Mental and Behavioural Disorders; Depression

• Registration Number: ISRCTN03693000
• Lead Sponsor: European Commission (Belgium)

Brief Summary

2009 Results article in http://www.ncbi.nlm.nih.gov/pubmed/19832967 results 2010 Results article in http://www.ncbi.nlm.nih.gov/pubmed/20360315 results 2011 Results article in http://www.ncbi.nlm.nih.gov/pubmed/21411156 results 2011 Results article in http://www.ncbi.nlm.nih.gov/pubmed/21388237 results 2011 Results article in http://www.ncbi.nlm.nih.gov/pubmed/22127194 results 2012 Results article in http://www.ncbi.nlm.nih.gov/pubmed/21926427 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24257813 results 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31318184 results (added 19/07/2019) 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30698114 results 2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31900198 results (added 06/01/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34598835/ Secondary analysis of inflammatory markers (added 04/10/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-09-27
• Study Completion: 2008-12-31
• Last Update Posted: 18 October 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1. A diagnosis of major depressive episode of at least moderate severity, as defined by the International Classification of Diseases, version 10 (ICD-10) or the Diagnostic and Statistical Manual of mental disorders - fourth edition (DSM-IV) and established in the Schedules for Clinical Assessment in Neuropsychiatry interview (SCAN version 2.1, World Health Organisation [WHO], 1999)
2. White European parentage
3. Aged 18 to 65 years
4. Participants with mild depressive symptoms on antidepressant treatment can be included if there is a history of moderate or severe symptoms during the current depressive episode
5. Individuals aged over 65 can be included if they are medically fit and not taking regular medication other than antidepressants

Exclusion Criteria

1. Family history of bipolar affective disorder or schizophrenia in first-degree relatives
2. A personal history of hypomanic or manic episode
3. Schizophrenia
4. Mood incongruent psychotic symptoms
5. Primary substance misuse
6. Primary organic brain disease
7. Current treatment with an antipsychotic or a mood stabiliser
8. Pregnancy or lactation
9. Medical contraindications or a history of lack of efficacy or adverse reaction to both study medications
10. Previous adverse reactions or non-response to either escitalopram or citalopram are considered as contraindications to escitalopram

Study & Design

• Study Type: Interventional
• Study Design: Not specified