Association Between Iron Reserves and Perioperative Neurocognitive Disorders

Completed

• Conditions: Perioperative Neurocognitive Disorders
• Interventions: Other: no intervention

• Registration Number: NCT06502912
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Iron metabolism disorder have been identified as the pivotal contributor in the pathogenesis and progression of perioperative neurocognitive disorders. However, the association between iron reserves and perioperative neurocognitive disorders risk remains elusive. This retrospective cohort study aimed to explore the impact of preoperative serum ferritin levels on the risk of postoperative delirium in elderly patients undergoing non-neurosurgical and non-cardiac procedures.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2024-07
• Study First Submitted: 2024-07-02
• Study First Submitted QC: 2024-07-09
• Last Update Submitted: 2024-07-09
• Study First Posted: 2024-07-16
• Last Update Posted: 2024-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12984

Inclusion Criteria

• Geriatric surgical patients ≥65 years old

Exclusion Criteria

• preoperative use of antipsychotics
• diagnosis or history description of preoperative cognitive disorders including dementia and Parkinson's

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
elderly patients (aged ≥ 65 years)	no intervention	elderly patients undergoing non-neurosurgical and non-cardiac procedures

Primary Outcome Measures

Name	Time	Method
Number of participants with postoperative delirium	Within the first seven days following surgery	Medical chart review was used for postoperative delirium determination in this study. The defining criteria were as follows: 1) delirium-related terms included in postoperative medical records or 2) postoperative record of delirium or psychotropic drugs treatment.