Association Between Iron Reserves and Perioperative Neurocognitive Disorders
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Perioperative Neurocognitive Disorders
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 12984
- Primary Endpoint
- Number of participants with postoperative delirium
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Iron metabolism disorder have been identified as the pivotal contributor in the pathogenesis and progression of perioperative neurocognitive disorders. However, the association between iron reserves and perioperative neurocognitive disorders risk remains elusive. This retrospective cohort study aimed to explore the impact of preoperative serum ferritin levels on the risk of postoperative delirium in elderly patients undergoing non-neurosurgical and non-cardiac procedures.
Investigators
Weidong Mi
Director (Cheif expert of National key research and development program of China 2018YFC2001900)
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Geriatric surgical patients ≥65 years old
Exclusion Criteria
- •preoperative use of antipsychotics
- •diagnosis or history description of preoperative cognitive disorders including dementia and Parkinson's
Outcomes
Primary Outcomes
Number of participants with postoperative delirium
Time Frame: Within the first seven days following surgery
Medical chart review was used for postoperative delirium determination in this study. The defining criteria were as follows: 1) delirium-related terms included in postoperative medical records or 2) postoperative record of delirium or psychotropic drugs treatment.