Assessment of subclinical atherosclerosis demonstrated by coronary artery calcification in familial hypercholesterolemia patients compared with non-familial hypercholesterolemia patients

Phase 1

Recruiting

• Conditions: familial hypercholesterolemianon- familial hypercholesterolemia; coronary artery calcium score; aortic valve calcium score; hypercholesterolemia

• Registration Number: TCTR20201014001
• Lead Sponsor: Ratchadaphiseksomphot Endowment Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-14
• Study Completion: 2020-12-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1 Age > 18 years old
2 Diagnosed with definite or probable familial hypercholesterolemia by Dutch Lipid Clinic Network criteria [FH group] or LDL more than 130 mg/dl [non-FH hypercholesterolemia group]

Exclusion Criteria

1 Secondary hypercholesterolemia eg.hypothyroidism, cholestasis, nephrotic syndrome, cushing syndrome, drug-induced
2 History of coronary artery disease, ischemic stroke
3 pregnancy
4 Have CT coronary contraindication or cannot withhold breathing during CT procedure

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary artery calcium score 6 months after CT scan CT coronary artery

Secondary Outcome Measures

Name	Time	Method
Aortic valve calcium score 6 months after CT scan CT coronary artery