CO2 gap and weaning outcome from mechanical ventilatio
- Conditions
- Mechanical ventilationRespiratory
- Registration Number
- ISRCTN10162509
- Lead Sponsor
- Centre Hospitalier de Lens
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 85
1. Aged 18 years or older
2. Under mechanical ventilation for at least 48 hours
3. Satisfied the weaning criteria. The readiness to wean criteria were:
3.1 The resolution or improvement of the underlying cause of respiratory failure for which the patient was intubated
3.2 Hemodynamic stability, defined as heart rate (HR) < 140/min and systolic blood pressure between 90 and 160 mmHg with no or minimal doses of vasopressors
3.3 Stable respiratory status, defined as oxygen saturation >90% with fraction of inspired oxygen (FiO2) =0.4 and positive end expiratory-pressure (PEEP) =8 cmH2O, respiratory rate (RR) =35/min, spontaneous tidal volume (Vt) >5 mL/kg, ratio of RR/Vt <105/min per liter, and no significant respiratory acidosis
3.4 Adequate mental status (Glasgow Coma Scale score >13)
3.5 Adequate cough.
4. Patients also had to have an arterial catheter and a central line with the tip confirmed by x-ray to be in the superior vena cava near at the entrance or in the right atrium.
1. Tracheotomized patients
2. Do-not-reintubate orders
3. Pregnancy
4. No informed consent
5. Poor cardiac echogenicity
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Weaning failure rate from mechanical ventilation defined as the development of at least one of the following:<br> 1. Respiratory acidosis with pH <7.32 and arterial CO2 pressure (PaCO2) >45 mmHg<br> 2. Arterial oxygen saturation <90% with FiO2 >0.5<br> 3. RR>35/min<br> 4. Clinical signs of respiratory fatigue<br>
- Secondary Outcome Measures
Name Time Method