Combination of central venous-to-arterial PCO2 difference and central venous oxygen saturation accurately predict weaning outcome from mechanical ventilation

Centre Hospitalier de Lens0 个研究点目标入组 85 人开始时间: 2019年9月6日最近更新: 2019年10月7日

适应症

试验速览

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•1. Aged 18 years or older
•2. Under mechanical ventilation for at least 48 hours
•3. Satisfied the weaning criteria. The readiness to wean criteria were:
•3.1 The resolution or improvement of the underlying cause of respiratory failure for which the patient was intubated
•3.2 Hemodynamic stability, defined as heart rate (HR) < 140/min and systolic blood pressure between 90 and 160 mmHg with no or minimal doses of vasopressors
•3.3 Stable respiratory status, defined as oxygen saturation >90% with fraction of inspired oxygen (FiO2) =0.4 and positive end expiratory-pressure (PEEP) =8 cmH2O, respiratory rate (RR) =35/min, spontaneous tidal volume (Vt) >5 mL/kg, ratio of RR/Vt <105/min per liter, and no significant respiratory acidosis
•3.4 Adequate mental status (Glasgow Coma Scale score >13)
•3.5 Adequate cough.
•4. Patients also had to have an arterial catheter and a central line with the tip confirmed by x-ray to be in the superior vena cava near at the entrance or in the right atrium.

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