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Clinical Trials/ISRCTN10162509
ISRCTN10162509
Completed
未知

Combination of central venous-to-arterial PCO2 difference and central venous oxygen saturation accurately predict weaning outcome from mechanical ventilation

Centre Hospitalier de Lens0 sites85 target enrollmentSeptember 6, 2019
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ConditionsRespiratoryMechanical ventilation

Overview

Phase
未知
Intervention
Not specified
Conditions
Respiratory
Sponsor
Centre Hospitalier de Lens
Enrollment
85
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
September 6, 2019
End Date
February 20, 2018
Last Updated
6 years ago
Study Type
Observational
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •1\. Aged 18 years or older
  • •2\. Under mechanical ventilation for at least 48 hours
  • •3\. Satisfied the weaning criteria. The readiness to wean criteria were:
  • •3\.1 The resolution or improvement of the underlying cause of respiratory failure for which the patient was intubated
  • •3\.2 Hemodynamic stability, defined as heart rate (HR) \< 140/min and systolic blood pressure between 90 and 160 mmHg with no or minimal doses of vasopressors
  • •3\.3 Stable respiratory status, defined as oxygen saturation \>90% with fraction of inspired oxygen (FiO2\) \=0\.4 and positive end expiratory\-pressure (PEEP) \=8 cmH2O, respiratory rate (RR) \=35/min, spontaneous tidal volume (Vt) \>5 mL/kg, ratio of RR/Vt \<105/min per liter, and no significant respiratory acidosis
  • •3\.4 Adequate mental status (Glasgow Coma Scale score \>13\)
  • •3\.5 Adequate cough.
  • •4\. Patients also had to have an arterial catheter and a central line with the tip confirmed by x\-ray to be in the superior vena cava near at the entrance or in the right atrium.

Exclusion Criteria

  • •1\. Tracheotomized patients
  • •2\. Do\-not\-reintubate orders
  • •3\. Pregnancy
  • •4\. No informed consent
  • •5\. Poor cardiac echogenicity

Outcomes

Primary Outcomes

Not specified

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