Investigation of the effect of concentrated beetroot juice consumption in patients with type 2 diabetes

Phase 3

Recruiting

Conditions: Diabetes.
Diabetes mellitus due to underlying condition

Registration Number: IRCT20150815023617N5

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

???Tendency to cooperate
Patients with type 2 diabetes for 1-10 years
Age between 35 to70 years old
BMI between 20-25 kg/m2
No pregnancy or breast-feeding
Patients who are only being treated with oral hypoglycemic agents
No alcohol and substance abuse history

Exclusion Criteria

Patients who are using insulin
Having chronic kidney, liver, or inflammatory diseases
Taking multivitamin and herbal supplements in the past 3 months
Taking glucocorticoids and nonsteroidal anti-inflammatory drugs
Taking of nitrate-containing drugs such as nitroglycerin, isosorbide, nitropress, etc.
History of microvascular and macrovascular diseases (such as history of angioplasty, foot vascular surgery)
Patients with uncontrolled diabetes (HbA1C more than or equal 8.5%)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma level of fasting plasma glucose. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Measuring by the colorimetric method based on the enzymatic reactions of invertase and glucose oxidase-peroxidase (GOD-POD).;HbA1C. Timepoint: At the beginning (before the start of the study) and at the end of the study (12 weeks after the start of beet juice consumption). Method of measurement: Chromatography.;HOMA-ß: The homeostasis model assessment of pancreatic ß-cell function. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-B=20× Insulin (µU/m/glucose(mg/dl) -3.5.;HOMA-IR: Homeostatic model assessment of insulin resistance. Timepoint: At the beginning (before the start of the study) and at the end of the study. Method of measurement: Calculating by formula: HOMA-IR=(glucose(mg/dl)× Insulin(µU/ml))/22.5.

Secondary Outcome Measures