Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults

Not Applicable

Completed

• Conditions: Nasal Obstruction; Exposure to Pollution
• Interventions: Other: rhinopharyngeal retrograde clearance (RRC)

• Registration Number: NCT01976039
• Lead Sponsor: University of Sao Paulo

Brief Summary

Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis, and instillation the nasal cavity with saline has been used to reduce nasal inflammation in rhinitis and sinusopathies. The aim of this study was to assess the effects of RRC and RCC combined with saline (RRC+S) on nasal mucociliary clearance (MCC), mucus surface property, cellularity and airways symptoms in professional motorcyclists.

Detailed Description

Male motorcyclists (mean age 36 years) were recruited and randomly assigned to RRC or RRC+S. Subjects were assessed at baseline and 15 days after interventions for saccharin test, mucus contact angle, cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire. Data were analyzed by two-way ANOVA for repeated measures with Bonferroni´s correction. A passive monitoring-system of nitrogen dioxide was used to assess the individual air pollution exposure along the study period. The association between nitrogen dioxide and the airways outcomes was analyzed by Spearman correlation test.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2012-07
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Study First Submitted: 2013-10-29
• Study First Submitted QC: 2013-11-04
• Study First Posted: 2013-11-05
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-17
• Last Update Posted: 2018-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Professional motorcyclists aged 18 years to 45 years
• Minimum of one year in that occupation
• Agreement with the written informed consent

Read More

Exclusion Criteria

• Smokers
• Inability to understand and to follow commands
• Previous nasal surgery
• Respiratory infection in the previous 30 days

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RRC+S	rhinopharyngeal retrograde clearance (RRC)	retrograde rhinopharyngeal retrograde clearance combined with saline instillation (RRC+S): patient sits in a chair and inhaled air and make noise and vibrate the upper airway at the same instills saline into the nare to facilitate nose washing and swalling. This technique is new, simple to use and with low cost (only saline).
RRC	rhinopharyngeal retrograde clearance (RRC)	rhinopharyngeal retrograde clearance (RRC) isolated: First patient sits in a chair. Second: patient inhales air deeply and exhales making noise and vibration in the upper airway to facilitate swalling. Third patients finishes with another deep inhalation. This technique is new, simple to use and with no cost. No need of any material or equipment.

Primary Outcome Measures

Name	Time	Method
Saccharine transit time test (STT)	15 days	To measure nasal mucociliary clearance. Subjects were asked to report the first perception of a sweet taste after 25 mg of saccharine powder was deposited in the free airflow nostril.

Secondary Outcome Measures

Name	Time	Method
mucus surface property	15 days	The contact angle of nasal mucus was measured.

Trial Locations

Locations (2)

Universidade Federal de Minas Gerais; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil

Faculdade de Medicina da Universidade de São Paulo; 🇧🇷 São Paulo, Brazil