The effect of a high caloric meal on brown fat activity and the role of the sympathetic nervous system in brown fat activatio

Completed

• Conditions: Obesity and its related metabolic diseases such as type 2 diabetes; Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN21413505
• Lead Sponsor: Maastricht University (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-02
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

1. Healthy lean and obese adults
2. Age 18-30 years
3. Male
4. Lean: BMI 18.5-25 kg/m2 or obese: BMI = 30 kg/m2
5. Caucasians

Exclusion Criteria

1. Diabetes mellitus
2. Hyperthyroidism
3. Cardiovascular and renal diseases
4. Tachy-arrhythmias
5. Asthma and other obstructive pulmonary diseases
6. Hypertension (systolic/diastolic blood pressure >140/90)
7. Hypotension (systolic/diastolic blood pressure <90/60)
8. Elevated fasting blood glucose level (> 5.6 mmol/L)
9. Medication: use of ß-blockers, tricylic antidepressants, MAO inhibitors
10. Glaucoom: use of the medicine betamimeticum

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Standard uptake values (SUVs) of brown adipose tissue - skeletal muscle mitochondrial respiration/uncoupling<br>2. Energy expenditure

Secondary Outcome Measures

Name	Time	Method
1. Body temperatures - Skin perfusion<br>2. Body composition - Blood parameters