nderstanding individual variation in treatment response in type 2 diabetes

Not Applicable

Completed

• Conditions: Topic: Diabetes Research Network; Subtopic: Type 2; Disease: Diabetic Control; Nutritional, Metabolic, Endocrine; Type 2 diabetes

• Registration Number: ISRCTN91540163
• Lead Sponsor: Royal Devon and Exeter NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-06-12
• Study Completion: 2014-10-31
• Last Update Posted: 9 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Age between 19 and 79 years
2. Clinical diagnosis of Type 2 Diabetes
3. Currently treated with sulphonylurea tablets
4. No change in diabetes treatment (new treatments or dose change) within last 3 months
5. Last HbA1c (taken within last 12 months) of =42 mmol/mol and =75 mmol/mol (6-9%)
6. Able and willing to monitor home blood glucose
7. Able and willing to give informed consent

Exclusion Criteria

1. Current treatment includes: insulin, GLP-1 agonists, DPP-IV inhibitors, glinides, Renal impairment (eGFR <30 ml/min/1.73m2)
2. Active infection (any infection requiring antibiotics at present)
3. Recent (within 3 months) surgery or planned surgery
4. Cardiovascular disease (angina, myocardial infarction, stroke, transient ischemic episode) occurring within the previous 3 months
5. Previous history of pancreatitis
6. Pregnant, breastfeeding or planning a pregnancy over the study period
7. Unable/unwilling to monitor home blood glucose

Study & Design

• Study Type: Interventional
• Study Design: Not specified