Development of hyperglycemic glucose clamp methods and evaluation of its outcomes in healthy subjects - Development of hyperglycemic glucose clamp methods and evaluation of its outcomes in healthy subjects

Hyperglycemic state was maintained in all six subjects. Results of insulin and C-peptide indicated effectiveness of our methods to evaluate the first- and second- insulin secretory ability quantitatively. No AE including clinically significant decrease of Potassium was observed, and our methods were considered technically safe.