Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

Not Applicable

Completed

• Conditions: Infertility Unexplained; Endometriosis
• Interventions: Procedure: Laparoscopic Exploration; Diagnostic Test: Estimation of Plasma Expression level of MICRO RNA 203 & 210

• Registration Number: NCT05680350
• Lead Sponsor: Benha University

Brief Summary

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-07
• Primary Completion: 2021-11-12
• Study Completion: 2022-03-25
• Status Verified: 2022-12
• Study First Submitted: 2022-12-26
• Study First Submitted QC: 2023-01-10
• Last Update Submitted: 2023-01-10
• Study First Posted: 2023-01-11
• Last Update Posted: 2023-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• 30-45 years old
• Unexplained infertility

Exclusion Criteria

• Presence of other causes of infertility,
• age out of the predetermined range,
• the presence of immune disorders,
• maintenance on immunosuppressive drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Study group	Laparoscopic Exploration	Study group Patients with unexplained infertility had estimated their Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR followed by laparoscopic exploration
Study group	Estimation of Plasma Expression level of MICRO RNA 203 & 210	Study group Patients with unexplained infertility had estimated their Plasma Expression level for Gene"Micro RNA "203 \& 210" by qRT-PCR followed by laparoscopic exploration
Control Group	Laparoscopic Exploration	Control group Patients with unexplained infertility underwent laparoscopy only

Primary Outcome Measures

Name	Time	Method
grading of endometriosis	8 months	The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis

Trial Locations

Locations (1)

Banha University; 🇪🇬 Banhā, El- Qalyobia, Egypt