Association of Serum Uromodulin and DKD a Systematic Review and Meta Analysis

Tanta University1 site in 1 country1,774 target enrollmentMay 1, 2024

ConditionsDiabetic Nephropathies

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Diabetic Nephropathies
Sponsor: Tanta University
Enrollment: 1774
Locations: 1
Primary Endpoint: Association of serum uromodulin with DKD: asystematic review and meta analysis
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Registry

clinicaltrials.gov

Start Date

May 1, 2024

End Date

May 30, 2024

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Tanta University

Responsible Party

Principal Investigator

Shaimaa Ibrahim Barr

Dr of Biochemistry

Tanta University

Eligibility Criteria

Inclusion Criteria

•Studies were included if they met the following criteria:
•serum level of uromodulin was determined;
•the samples were enrolled from diabetic patients;
•mean ± SD was reported for uromodulin between patients with and without DN;
•the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion Criteria

•Studies were excluded according to the following criteria:
•duplicate studies;
•review articles;
•non original research articles;
•studies with insufficient data to extract;
•non-human research;
•studies that determined urine level of uromodulin.

Outcomes

Primary Outcomes

Association of serum uromodulin with DKD: asystematic review and meta analysis

Time Frame: may, 2024

Evaluate the meta analysis of association of serum uromodulin in the 3 diabetic group comparing with each other and compare them to the control group and correlate these results with other kidney biomarker