Hemostasis in Patients With Idiopathic Thrombocytopenic Purpura
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- maximum clot formation
研究概览
简要总结
The investigators are trying to investigate the coagulation status of idiopathic (immune) thrombocytopenic purpura patients by measuring the platelet count, coagulation battery, von Willebrand factor level, thromboelastography.
详细描述
In patients with chronic coagulation disorder, laboratory model and clinical data have shown evidence for a rebalanced hemostasis. Previous study showed that the platelet count may not predict the risk of bleeding since the platelet count is not an indicator of platelet function. Thromboelastography may be the choice of investigation when platelet function is in question especially in patients with idiopathic (immune) thrombocytopenic purpura (ITP). Previous study have shown that maximum clot formation is the most important thromboelastography parameter in predicting bleeding in ITP patients that makes thromboelastography superior to other hemostatic tests. The investigators are trying to evaluate the rebalanced hemostasis in patients with ITP by comparing the value of platelet count, von Willebrand factor antigen level, and thromboelastography parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Those who visits the outpatients clinic of Samsung Medical Center with a diagnosis of idiopathic (immune) thrombocytopenic purpura (ITP)between March, 2012 and February,
- •Those with age between 20 and 70 yrs old
排除标准
- •Those with other causes of thrombocytopenia other than ITP
结局指标
主要结局
maximum clot formation
时间窗: within 3 hour of blood sampling
thromboelastography parameters performed within 3 hours of blood sampling
次要结局
- platelet count(within 1 hours of blood sampling)
- Coagulation battery results(within 1 hour after blood sampling)
- von Willebrand factor antigen(within 3 hours of blood sample)
- clotting time(within 3 hours of blood sampling)
- alpha angle(within 3 hours of blood sample)
- A10, A15, A20, A25(within 3 hours of blood sampling)
- LY 60(within 3 hours of blood sampling)
- CLI(within 3 hours of blood sampling)
- Maximum lysis(within 3 hours of blood sampling)
研究者
Gaab Soo Kim
Professor
Samsung Medical Center