Immunochemical FOBT screening for colorectal cancer: yield and attendance for one- versus two-sample tests, and for second round screening with various intervals.
Recruiting
- Conditions
- Colorectal cancer
- Registration Number
- NL-OMON26711
- Lead Sponsor
- Erasmus Medical Center, RotterdamDepartment of Gastroenterology and Hepatology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Asymptomatic individuals aged 50-75 years old, who are able to provide an informed consent.
Exclusion Criteria
1. Inability or refusal to provide informed consent
2. History of CRC or inflammatory bowel disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Adherence for second round CRC screening with 1-sample iFOBT (OC-Hemodia Latex) comparing annual, biennial, and triennial screening interval.<br /><br>Adherence and diagnostic yield of a first screening round comparing 1-sample versus 2-sample iFOBT screening.
- Secondary Outcome Measures
Name Time Method The diagnostic yield of the various intervals of a second round iFOBT screening.<br>The feasibility and required colonoscopy capacity needed for further evaluation of participants with a positive iFOBT screening.<br>Side effects of screening.<br /><br>Participants’ experiences; the acceptability, satisfaction and burden of screening in different rounds and use of one or two-sample iFOBT.<br /><br>Reasons for non-participation.<br /><br>The cost-effectiveness ratio of the three different screenings-intervals and the one and two-sample iFOBT.